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US 11,028,057 B2Granted
Process for the synthesis of 6-chloromethyluracil
AssigneeProcos S.P.A.
InventorsFabio Morana, Stefano Gobbato, Jacopo Roletto, Paolo Paissoni
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Abstract
The invention relates to a process for the synthesis of 6-chloromethyluracil (6-(chloromethyl)pyrimidin-2,4(1H,3H)-dione) from ethyl 4-chloroacetoacetate and S-methylisothiourea hemisulfate via isolation of the novel intermediate 6-(chloromethyl)-6-hydroxy-2-(methylthio)-5,6-dihydropyrimidin-4(1H)-one, and its subsequent treatment with aqueous sulfuric acid. Formula (I).
Claims7
A process for the preparation of 6-chloromethyluracil comprising the following steps:
- a) reacting ethyl 4-chloroacetoacetate and S-methylisothiourea hemisulfate to yield the isolated intermediate 6-(chloromethyl)-6-hydroxy-2-(methylthio)-5,6-dihydropyrimidin-4(1H)-one;
- b) reacting said 6-(chloromethyl)-6-hydroxy-2-(methylthio)-5,6-dihydropyrimidin-4(1H)-one with aqueous sulfuric acid to yield 6-chloromethyluracil.
The compound 6-(chloromethyl)-6-hydroxy-2-(methylthio)-5,6-dihydropyrimidin-4(1H)-one.
Dependencies are inferred from the claim text.