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US 11,028,055 B2Granted
Compounds for treating proliferative diseases
AssigneesChildren's Medical Center Corporation, Beth Israel Deaconess Medical Center, Inc.
InventorsBruce R. Zetter, Lijun Sun
Life of this patent
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Abstract
The present disclosure provides compounds of Formula (I). The compounds described herein may be useful in treating and/or preventing proliferative diseases (e.g., cancer). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein.
Claims18
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is substituted or unsubstituted alkyl, substituted or unsubstituted carbocyclyl, or substituted or unsubstituted heterocyclyl;
- R2 is of the formula
- RA2 is —N(RC)2, and each instance of RC is independently substituted or unsubstituted alkyl, or substituted or unsubstituted heterocyclyl;
- RA3 is —N(RA4)2, and two instances of RA4 are joined to form a substituted or unsubstituted, heteroaryl ring;
- RA6 is —N(RA7)2, and two instances of RA7 are joined to form a substituted or unsubstituted, heterocyclic ring, or substituted or unsubstituted, heteroaryl ring;
- R3 is independently hydrogen, substituted or unsubstituted C1-6 alkyl, or a nitrogen protecting group;
- and
- R4 is independently hydrogen, substituted or unsubstituted C1-6 alkyl, or a nitrogen protecting group.
6 more elements
A compound of the formula:
- or a pharmaceutically acceptable salt thereof.
A compound of the formula:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.