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US 11,028,050 B2Granted
Salts and polymorphs of a PDE4 inhibitor
AssigneeTetra Discovery Partners, LLC
InventorsMark E. Gurney, Jon P. Lawson, Stephan D. Parent, Richard James Ely
Life of this patent
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Abstract
Provided herein are free base crystalline forms and crystalline salts of Compound 1.
Claims16
A crystalline form of free base Compound 1 (Form A), characterized by an X-ray powder diffraction (XRPD) pattern comprising peaks at 12.72, 15.90, 19.39, 20.80, 20.98, 23.15, and 26.08,±0.2° 2θ using Cu Kα radiation.
A crystalline form of Compound 1 selected from the group consisting of
- (a) Compound 1 and p-dioxane (Form B), characterized by an X-ray powder diffraction (XRPD) pattern comprising peaks at 20.02, 20.29, 21.32, 21.51, and 23.57,±0.2° 2θ using Cu Kα radiation,
- (b) Compound 1 and dichloromethane (Form C), characterized by an X-ray powder diffraction (XRPD) pattern comprising peaks at 4.59, 13.00, 19.09, 21.74, 22.27, 23.82, and 24.11,±0.2° 2θ using Cu Kα radiation;
- (c) Compound 1 calcium salt (Form D), characterized by an X-ray powder diffraction (XRPD) pattern comprising peaks at 6.10, 9.17, 15.68, 19.86, and 26.46,±0.2° 2θ using Cu Kα radiation;
- (d) Compound 1 potassium salt (Form E), characterized by an X-ray powder diffraction (XRPD) pattern comprising peaks at 3.02, 3.88, 6.07, 7.01, and 8.32,±0.2° 2θ using Cu Kα radiation;
- (e) Compound 1 potassium salt (Form F), characterized by an X-ray powder diffraction (XRPD) pattern comprising peaks at 3.8, 7.1, 7.5, 8.6, 9.4, 18.1, and 23.5, ±0.2° 2θ using Cu Kα radiation;
- (f) Compound 1 sodium salt (Form G), characterized by an X-ray powder diffraction (XRPD) pattern comprising peaks at 3.93, 19.66, 20.48, and 21.10,±0.2° 2θ using Cu Kα radiation;
- and
- (b) Compound 1 sodium salt (Form H), characterized by an X-ray powder diffraction (XRPD) pattern comprising peaks at 7.09, 8.39, 19.56, 23.64, and 24.70,±0.2° 2θ using Cu Kα radiation.
5 more elements
Dependencies are inferred from the claim text.