US 11,027,276 B2Granted

Film bag for a microfluidic analysis system, microfluidic analysis system, method for producing and method for operating a microfluidic analysis system

AssigneeRobert Bosch GmbH

InventorsChristian Dorrer, Daniel Czurratis, Jochen Rupp, Karsten Seidl, Thomas Brettschneider

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Abstract

A film bag for a microfluidic analysis system includes a film bag bottom, a film bag opening arranged opposite the film bag bottom, and a peel seam arranged between the film bag bottom and the film bag opening. The peel seam is formed to produce a closed reagent receiving region between the peel seam and the film bag bottom and a tube between the peel seam and the film bag opening. The reagent receiving region has a reagent receiving length extending between the peel seam and the film bag bottom. The tube has a tube length extending between the peel seam and the film bag opening. The tube length is at least five percent of the reagent receiving length.

Claims19

Dependent claims

A film bag for a microfluidic analysis system, comprising:

a film bag bottom;
a film bag opening arranged opposite the film bag bottom;
and
a peel seam defining a predetermined breaking point at a location between the film bag bottom and the film bag opening, the peel seam configured to define at least in part (i) a closed reagent receiving region between the peel seam and the film bag bottom, and (ii) a tube region of the film bag located between the peel seam and the film bag opening,
wherein the film bag is configured such that when a fluid is in the closed reagent receiving region and the peel seam is released at the predetermined breaking point, the closed reagent receiving region is opened at the predetermined breaking point and the fluid is directed from the reagent receiving region through the predetermined breaking point and then through the tube region and then out of the film bag through the film bag opening,
wherein the reagent receiving region has a reagent receiving length extending between the peel seam and the film bag bottom, and
wherein the tube region has a tube length extending between the peel seam and the film bag opening, the tube length being at least five percent of the reagent receiving length.

4 more elements

A microfluidic analysis system, comprising:

a container with at least one first tube chamber and a second tube chamber arranged adjacent to the first tube chamber;
at least one first film bag, the first film bag including:
a first film bag bottom,
a first film bag opening arranged opposite the first film bag bottom, and
a first peel seam defining a first predetermined breaking point at a location between the first film bag bottom and the first film bag opening, the first peel seam configured to define at least in part (i) a first closed reagent receiving region between the first peel seam and the first film bag bottom, and (ii) a first tube region between the first peel seam and the first film bag opening,
wherein the first film bag is configured such that when a fluid is in the first closed reagent receiving region and the first peel seam is released at the first predetermined breaking point, the first closed reagent receiving region is opened at the first predetermined breaking point and the fluid is directed from the first reagent receiving region through the first predetermined breaking point and then through the first tube region and then out of the first film bag through the first film bag opening,
wherein the first reagent receiving region has a first reagent receiving length extending between the first peel seam and the first film bag bottom, wherein the first tube region has a first tube length extending between the first peel seam and the first film bag opening, the first tube length being at least five percent of the first reagent receiving length;
and
a second film bag arranged adjacent to the first film bag, the second film bag including:
a second film bag bottom,
a second film bag opening arranged opposite the second film bag bottom, and
a second peel seam defining a second predetermined breaking point at a location between the second film bag bottom and the second film bag opening, the second peel seam configured to define in part (i) a second closed reagent receiving region between the second peel seam and the second film bag bottom, and (ii) a second tube region between the second peel seam and the second film bag opening,
wherein the second reagent receiving region has a second reagent receiving length extending between the second peel seam and the second film bag bottom, wherein the second tube region has a second tube length extending between the second peel seam and the second film bag opening, the second tube length being at least five percent of the second reagent receiving length,
wherein at least one subsection of the first tube region of the first film bag, which subsection surrounds the first film bag opening, is accommodated by the first tube chamber,
wherein at least one subsection of the second tube region of the second film bag, which subsection surrounds the second film bag opening, is accommodated by the second tube chamber, and
wherein the first reagent receiving region of the first film bag and the second reagent receiving region of the second film bag are arranged outside the first and second tube chambers.

13 more elements

A method for producing a microfluidic analysis system, comprising:

arranging at least one first film bag adjacent to at least one second film bag, wherein:
the first film bag includes:
a first film bag bottom,
a first film bag opening arranged opposite the first film bag bottom, and
a first peel seam defining a first predetermined breaking point at a location between the first film bag bottom and the first film bag opening, the first peel seam configured to define at least in part (i) a first closed reagent receiving region between the first peel seam and the first film bag bottom, and (ii) a first tube region between the first peel seam and the first film bag opening,
wherein the first film bag is configured such that when a fluid is in the first closed reagent receiving region and the first peel seam is released at the first predetermined breaking point, the first closed reagent receiving region is opened at the first predetermined breaking point and the fluid is directed from the first reagent receiving region past the first predetermined breaking point and then through the first tube region and then out of the first film bag through the first film bag opening,
wherein the first reagent receiving region has a first reagent receiving length extending between the first peel seam and the first film bag bottom, wherein the first tube region has a first tube length extending between the first peel seam and the first film bag opening, the first tube length being at least five percent of the first reagent receiving length, and
the second film bag includes:
a second film bag bottom,
a second film bag opening arranged opposite the second film bag bottom, and
a second peel seam defining a second predetermined breaking point at a location between the second film bag bottom and the second film bag opening, the second peel seam configured to define at least in part (i) a second closed reagent receiving region between the second peel seam and the second film bag bottom, and (ii) a second tube region between the second peel seam and the second film bag opening,
wherein the second reagent receiving region has a second reagent receiving length extending between the second peel seam and the second film bag bottom, wherein the second tube region has a second tube length extending between the second peel seam and the second film bag opening, the second tube length being at least five percent of the second reagent receiving length;
accommodating at least one subsection of the first tube region of the first film bag by a first tube chamber of a container, the subsection of the first tube region surrounding the first film bag opening, and
accommodating at least one subsection of the second tube region of the second film bag by a second tube chamber of the container, the second tube chamber arranged adjacent to the first tube chamber, the subsection of the second tube region surrounding the second film bag opening;
and
arranging the reagent receiving region of the first film bag and the reagent receiving region of the second film bag outside the tube chambers.

13 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/379,062Filed 14 Dec 2016
Priority: DE 10 2015 225 837.818 Dec 2015
Published: US 2017/0173581 A122 Jun 2017
Granted: 8 Jun 2021
Term ends: Not estimatedThe source records don’t support an estimate.

Classification17 codes

B01L 3/50273
By integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g.…
B01L 3/502707
By integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g.…
B01L 3/502715
By integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g.…
B01L 3/52
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers: containers specially adapted for storing or dispensing a reagent

Family

US 2017/0173581 A1Pre-grant publication · published 22 Jun 2017
US 11,027,276 B2This patent

From the US filing history. Foreign family members aren’t listed.

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