Packed bed emulsification
AssigneeCytiva BioProcess R&D AB
InventorsJimmy Hedin Dahlstrom, Jonas Bengtsson, Per Erik Emilsson, Maranda Fordham, Eva Holmgren, Ronnie Palmgren, Fernando Polanco
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Abstract
A system and method for producing fine droplets of polysaccharide from a premixed water-in-oil emulsion uses a packed bed (5) comprising hydrophilic beads (7).
Claims25
A system for the production of polysaccharide droplets from a water-in-oil emulsion comprising, at least one chamber comprising an inlet side connectable to a source of water-in-oil emulsion containing droplets of an aqueous solution of a polysaccharide in an oil-based continuous phase, an outlet side, a packed bed of beads between the inlet side and the outlet side, and flow-producing means for providing a flow of water-in-oil emulsion through the packed bed to an outlet port, wherein the beads are hydrophilic beads, and a bed height of the packed bed is 10-70 mm.
A method for producing fine droplets of polysaccharide material from a water-in-oil premixed emulsion characterized in that it comprises the following steps:
- providing a chamber with a packed bed of hydrophilic beads, wherein a bed height of the packed bed is 10-70 mm;
- passing a water-in-oil premixed emulsion comprising coarse droplets of aqueous polysaccharide solution in an oil through the packed bed to form fine droplets;
- and,
- optionally recirculating the fine droplets through the packed bed.
Dependencies are inferred from the claim text.