Intradermal jet injection electroporation device

An electroporation device for use with an agent cartridge defining a volume containing a pre-measured dose of agent therein, the electroporation device comprising:

• a housing defining a cavity sized to receive at least a portion of the agent cartridge therein;
• a jet-injection nozzle at least partially positioned within the housing and in fluid communication with the agent cartridge when the agent cartridge is positioned within the cavity;
• a propulsion rod positioned at least partially within the housing and movable with respect thereto between an armed position and a deployed position, and wherein movement of the propulsion rod from the armed position to the deployed position expels at least a portion of the pre-measured dose of the agent through the jet-injection nozzle;
• a propulsion spring extending between the propulsion rod and the housing, the propulsion spring configured to bias the propulsion rod toward the deployed position;
• an array having one or more electrodes extending therefrom, the array mounted to a support slide that is axially moveable with respect to the housing and the jet-injection nozzle between a retracted position, in which the one or more electrodes are positioned inside the housing, and an extended position, in which at least a portion of the one or more electrodes are positioned outside the housing;
• a power supply;
• and
• a trigger assembly adjustable between a first configuration, where the propulsion rod is fixed in the armed position and the power supply is not in electrical communication with the array, and a second configuration, where the propulsion rod is free to move between the armed and deployed positions and the power supply is in electrical communication with the array.

An electroporation device comprising:

• a cartridge defining a volume having a pre-measured dose of agent therein, at least a portion of the volume being sealed off by a plunger;
• a jet injection module including:
• a first housing defining a cavity sized to receive at least a portion of the cartridge therein;
• a jet-injection nozzle at least partially positioned within the first housing and in fluid communication with the cartridge when the cartridge is positioned within the cavity;
• an array having one or more electrodes extending therefrom, wherein the array is mounted to a support slide that is axially movable with respect to the first housing and the jet-injection nozzle between a retracted position, where the one or more electrodes are positioned within the first housing, and an extended position, where at least a portion of the one or more electrodes are positioned outside the first housing;
• and
• a base assembly being removably couplable to the jet injection module, the base assembly including:
• a propulsion rod positioned at least partially within a second housing and movable with respect thereto between an armed position and a deployed position, and wherein the propulsion rod is configured to operatively engage the cartridge,
• a propulsion spring extending between the propulsion rod and the second housing, the propulsion spring configured to bias the propulsion rod toward the deployed position;
• a power supply, and
• a trigger assembly adjustable between a first configuration, where the propulsion rod is fixed in the armed position and the power supply is not in electrical communication with the array, and a second configuration, where the propulsion rod is free to move between the armed and deployed positions and the power supply is in electrical communication with the array.