US 11,027,045 B2 · Synthetic niche matrices for stem cell culture

Abstract

The present invention relates to a supermatrix of synthetic niches comprising at least two matrices of niches wherein each matrix comprises n×m niches and wherein the distance (d) between a matrix and the other is greater than zero and wherein in each matrix every synthetic niche has one or more walls in common with the others synthetic niches of the matrix. A support for the culture of cells that includes at least one supermatrix and the use of said supermatrix or support for the in vitro culture of cells, in particular stem cells, or for the in vivo implant in a subject in order to promote tissue or organ regeneration through cell repopulation are also within the scope of the present invention.

Claims20

Dependent claims

A supermatrix of synthetic niches comprising at least a first and a second matrix of synthetic niches,

wherein each matrix comprises n×m synthetic niches, wherein n and m, the same or different from each other, independently have a value ≥1, provided that one of m or n is ≥2 and with a maximum value of m and n which allows to maintain a structure of a single synthetic niche intact such that shrinking or contraction of the synthetic niche does not cause a disruption or detachment of a niche matrix, and
wherein a distance (d) between each synthetic niche matrix and another is greater than zero and
wherein in each matrix every synthetic niche has one or more walls in common with at least one other synthetic niche of the matrix.

Dependencies are inferred from the claim text.

Facts

Application

15/755,011Filed 31 Aug 2016

Priority

IT 1020150000487044 Sep 2015

Published

US 2020/0046881 A113 Feb 2020

Granted

8 Jun 2021

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

A61L 27/3834
Characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells: cells able to produce different…
A61L 27/50
Materials for grafts or prostheses or for coating grafts or prostheses: materials characterised by their function or physical properties , e.g.…
A61L 27/56
Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface…:…
C12N 5/0068
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor: general…

Synthetic niche matrices for stem cell culture

Life of this patent

Synthetic niche matrices for stem cell culture

Life of this patent

Abstract

Claims20