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US 11,027,027 B2Granted
Pyridazinoindole compounds and methods for PET imaging
AssigneeVanderbilt University
InventorsH. Charles Manning, Yiu-Yin Cheung, Jason R. Buck, Jun Li
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Abstract
Embodiments of the invention include a novel synthesis of the translocator protein (TSPO) ligands, and methods of imaging a molecular events. Also disclosed are compounds for treatment of diseases, including cancer.
Claims7
A compound of the following formula:
- wherein R1 and R2 are independently ethyl;
- and n is 8.
A method of quantifying the progression of a disease state in a subject, comprising:
- (a) administering to a first sample of the subject a conjugate, the conjugate comprising a TSPO affinity ligand of the following formula:
- wherein R1 and R2 are independently ethyl, and n is 8;
- (b) detecting a signal from said conjugate;
- (c) after a period of time from step (b), administering to a second sample of the subject a conjugate, the conjugate comprising TSPO affinity ligand of the following formula:
- wherein R1 and R2 are independently ethyl, and n is 8;
- (d) detecting a second signal;
- and
- (e) comparing the first signal with the second signal to determine the progress of a disease state.
5 more elements
Dependencies are inferred from the claim text.