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US 11,027,026 B2Granted
Polymer, and contrast agent for photoacoustic imaging, including the polymer
AssigneeCanon Kabushiki Kaisha
InventorsHideo Saji, Kohei Sano, Akira Makino, Kengo Kanazaki, Fumio Yamauchi, Satoshi Ogawa
Life of this patent
Estimating the term…
Abstract
To provide a polymer having a high tumor/blood ratio. The present invention provides a polymer represented by the following formula (P1): wherein in the formula (P1), R0 represents any of a residue or a functional group derived from a cationic polymerization initiator; L represents a linker and L may not be present; n represents an integer of 1 or more; D represents a dye backbone of a dye having absorption in the near-infrared region.
Claims14
A polymer represented by formula (A1):
- wherein in the formula (A1), R0 represents a residue derived from a cationic polymerization initiator, or a functional group;
- L1 represents a linker and L1 may not be present;
- D1 is represented by formula (d1-1);
- and Z1 represents a structure comprising at least one unit represented by formula (A2), at least one unit represented by formula (A3), and at least one unit represented by formula (A4):
- wherein in the formula (A2), D2 is represented by the formula (d1-1);
- and R1 to R4 each independently represents a hydrogen atom, or a substituted or unsubstituted hydrocarbon group having 1 to 4 carbon atoms, in which, when a substituent is present, the substituent is a functional group including at least one selected from the group consisting of a halogen atom, an oxygen atom and a nitrogen atom;
- wherein in the formula (A3), R1 to R4 each independently represents a hydrogen atom, or a substituted or unsubstituted hydrocarbon group having 1 to 4 carbon atoms, in which, when a substituent is present, the substituent is a functional group including at least one selected from the group consisting of a halogen atom, an oxygen atom, and a nitrogen atom;
- and
- R5 represents any of a methyl group, an ethyl group, an isopropyl group, a n-propyl group, a n-butyl group, a n-octyl group, a n-heptyl group, a phenyl group, a butenyl group, and a pentynyl group;
- wherein in the formula (A4), R1 to R4 each independently represents a hydrogen atom, or a substituted or unsubstituted hydrocarbon group having 1 to 4 carbon atoms, in which, when a substituent is present, the substituent is a functional group including at least one selected from the group consisting of a halogen atom, an oxygen atom, and a nitrogen atom, and
- wherein a ratio of a unit represented by the formula (A4) to repeating units of the polymer is 12.6% or less as measured by electric conductivity:
- wherein, in the formula (d1-1), * represents binding to L1 in the formula (A1) or represents binding to Z1 in the formula (A1) when L1 is not present.
9 more elements
Dependencies are inferred from the claim text.