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US 11,027,020 B2Granted
Delivery constructs for transcytosis and related methods
AssigneeApplied Molecular Transport Inc.
InventorsRandall J. Mrsny, Tahir Mahmood, Charles Olson, Weijun Feng, Sally Postlethwaite
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Abstract
The present disclosure provides non-naturally occurring fusion molecules comprising therapeutic cargo moieties, such as IL-22 with a carrier. The disclosure also provides methods and compositions for the production, purification, refolding, formulation, and administration of fusion molecules. Methods and for using the purified molecules to treat and prevent diseases or disorders are also provided herein.
Claims15
A delivery construct comprising a carrier coupled to a payload, wherein the delivery construct has at least 90% sequence identity to SEQ ID NO:
- 17, and wherein the carrier consists of the amino acid sequence set forth in SEQ ID NO:
- 7 or SEQ ID NO:
- 9, or an amino acid sequence having at least 95% sequence identity thereto.
Dependencies are inferred from the claim text.