Pharmaceutical preparation stably comprising CD147 monoclonal antibody
AssigneeXiaochun Chen
InventorsHao Tang, Qiang Feng, Tianyi Yang, Mingxi Chen
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Abstract
Disclosed is a pharmaceutical preparation comprising a CD147 monoclonal antibody, a buffer, a protein protectant and a surfactant. The pharmaceutical preparation can maintain the stability of the CD147 monoclonal antibody over a long period of time. Also disclosed are the use of the pharmaceutical preparation in the preparation of a drug for treating CD147-related diseases, in particular non-small cell lung cancer, and a method for preparing the pharmaceutical preparation.
Claims4
A pharmaceutical formulation, comprising a CD147 monoclonal antibody, a buffer, a protein protective agent and a surfactant, wherein the buffer is histidine buffer, the protein protective agent is sucrose, and the surfactant is polysorbate 80, wherein the concentration of the histidine buffer is 9-11 mmol/L, the concentration of the sucrose in the pharmaceutical formulation is 80-110 mg/ml, and the concentration of the polysorbate 80 in the pharmaceutical formulation is 0.35-0.45 mg/ml.
Dependencies are inferred from the claim text.