Loading patent…
AssigneeStallergenes
InventorsPhilippe Moingeon, Thierry Batard, Bertrand Villet
Estimating the term…
The invention relates to grass pollen extracts containing reduced amount of flavonoid glycosides in order to minimize the risks of genotoxicity of the grass pollen extracts. The invention also relates to a method of preparing grass pollen extracts containing reduced amount of flavonoid glycosides by ultrafiltration. Flavonoid glycosides are naturally present in grass pollen extracts and they have been identified as being responsible for the formation of flavonoid aglycones, which are genotoxic in vitro, under the influence of enzymes contained in the grass pollen extracts.
A pharmaceutical composition comprising a purified pollen extract containing pollen allergen comprising a mixture of cocksfoot, meadow grass, rye-grass, sweet vernal-grass and timothy grass extracts, wherein the composition contains an amount of each flavonoid that is less than 0.002 g per 100 g of pollen derived fraction, as expressed in aglycone equivalent, and a pharmaceutically acceptable carrier comprising a vaccination adjuvant selected from the group consisting of heat-labile enterotoxin, choleratoxin, cholera toxin B subunit, polymerized liposomes, and mutant toxins.
Dependencies are inferred from the claim text.