Insulin glargine/lixisenatide fixed ratio formulation

A method for improving glycemic control in a patient with type 2 diabetes mellitus inadequately controlled by treatment with insulin glargine and metformin, the method comprising administering to the patient in need thereof a therapeutically effective amount of a fixed ratio combination of:

• (a) lixisenatide or a pharmaceutically acceptable salt thereof, and
• (b) insulin glargine or a pharmaceutically acceptable salt thereof,
• wherein the fixed ratio combination is administered as a single daily injection;
• wherein the patient has been treated with metformin at a stable dose of at least 1.5 g per day for at least 3 months and has a HbA1c level between 7% and 10%;
• such that the administration of the fixed ratio combination improves glycemic control in the patient over treatment with insulin glargine and metformin.