Back to results
US 11,026,985 B2Granted
Methods for removing contaminants from plant-derived pharmaceuticals
AssigneeSorbent Technologies Corporation
InventorRobert Ralph Kerr
Life of this patent
Estimating the term…
Abstract
Methods of removing contaminants such as pesticides, herbicides, and fungicides from plant-derived pharmaceuticals, such as Cannabis-derived pharmaceuticals, are disclosed. Plant-derived pharmaceuticals, such as Cannabis-derived pharmaceuticals, and methods of using the plant-derived pharmaceuticals are also disclosed.
Claims20
A method of removing contaminants from a Cannabis plant-derived pharmaceutical, said method comprising:
- reacting one or more contaminants within a Cannabis plant-derived extract with an alkali metal hydroxide in a polar solvent to form one or more contaminant by-products in a reaction mixture, wherein said reacting step comprises:
- adding the Cannabis plant-derived extract to the alkali metal hydroxide in the polar solvent to form the reaction mixture;
- agitating the reaction mixture with mixing;
- and
- adding a neutralizing acid to the reaction mixture, wherein the neutralizing acid comprises glacial acetic acid, or a dilute mineral acid comprising hydrochloric acid, sulfuric acid, or nitric acid;
- and
- separating the one or more contaminant by-products from the Cannabis plant-derived extract so as to obtain a contaminant-reduced Cannabis plant-derived extract, wherein said separating step comprises:
- adding a first alkane to the reaction mixture so as to form a non-aqueous liquid phase within the reaction mixture, wherein the first alkane comprises butane, pentane, cyclopentane, hexane, cyclohexane, heptane, octane, isooctane, or any combination thereof;
- and
- separating an upper non-aqueous liquid phase from a lower aqueous liquid phase, the upper non-aqueous liquid phase comprising the first alkane and the contaminant-reduced Cannabis plant-derived extract,
- wherein the contaminant-reduced Cannabis plant-derived extract comprises one or more cannabinoids.
8 more elements
A method of removing contaminants from a plant-derived pharmaceutical, said method comprising:
- reacting one or more contaminants within a plant-derived extract with an alkali metal hydroxide in a polar solvent to form one or more contaminant by-products in a reaction mixture;
- and
- separating the one or more contaminant by-products from the reaction mixture so as to obtain a contaminant-reduced plant-derived extract,
- wherein said reacting step comprises:
- adding the plant-derived extract to the alkali metal hydroxide in the polar solvent to form the reaction mixture;
- agitating the reaction mixture with mixing;
- and
- adding a neutralizing acid to the reaction mixture, wherein the neutralizing acid comprises hydrochloric acid;
- and
- wherein said separating step comprises:
- adding a first alkane to the reaction mixture so as to form a non-aqueous liquid phase within the reaction mixture;
- separating an aqueous liquid phase of the reaction mixture from the non-aqueous liquid phase;
- passing the non-aqueous liquid phase through one or more columns with each column comprising one or more adsorbents;
- passing one or more column volumes of a rinse mixture through the one or more columns, the rinse mixture comprising a second alkane and ethyl acetate;
- and
- evaporating the rinse mixture under reduced pressure so as to (1) remove one or more of:
- (i) the first alkane, (ii) the second alkane, (iii) ethyl acetate, and (iv) any residual neutralizing acid, and (2) result in the contaminant-reduced plant-derived extract.
14 more elements
A method of removing contaminants from a plant-derived pharmaceutical, said method comprising:
- reacting one or more contaminants within a plant-derived extract with an alkali metal hydroxide in a polar solvent to form one or more contaminant by-products in a reaction mixture, the one or more contaminants comprising one or more pesticides, one or more herbicides, one or more fungicides, or any combination thereof;
- and
- separating (i) the one or more contaminant by-products, and (ii) a contaminant-reduced plant-derived extract from the reaction mixture,
- wherein said separating step comprises:
- adding a first alkane to the reaction mixture so as to form a non-aqueous liquid phase within the reaction mixture;
- separating an aqueous liquid phase of the reaction mixture from the non-aqueous liquid phase;
- passing the non-aqueous liquid phase through one or more columns with each column comprising one or more adsorbents;
- passing one or more column volumes of a rinse mixture through the one or more columns, the rinse mixture comprising a second alkane and ethyl acetate;
- and
- evaporating the rinse mixture under reduced pressure so as to (1) remove one or more of:
- (i) the first alkane, (ii) the second alkane, (iii) ethyl acetate, and (2) result in the contaminant-reduced plant-derived extract.
8 more elements
Dependencies are inferred from the claim text.