Nucleic acid molecules encoding chimeric antigen receptors comprising a CD20 binding domain

An isolated chimeric antigen receptor (CAR) molecule comprising a CD20 binding domain, a transmembrane domain, and an intracellular signaling domain, wherein the CD20 binding domain comprises a light chain complementarity determining region 1 (LCDR1), light chain complementarity determining region 2 (LCDR2), light chain complementarity determining region 3 (LCDR3) heavy chain complementarity determining region 1 (HCDR1), heavy chain complementarity determining region 2 (HCDR2), and heavy chain complementarity determining region 3 (HCDR3), wherein the LCDR1, LCDR2, LCDR3, HCDR1, HCDR2, and HCDR3 comprise:

• (i) SEQ ID NOs:
• 147, 148, 149, 136, 137, and 138, respectively;
• (ii) SEQ ID NOs:
• 150, 151, 152, 139, 140, and 141, respectively;
• (iii) SEQ ID NOs:
• 153, 154, 155, 142, 143, and 144, respectively;
• (iv) SEQ ID NOs:
• 929, 930, 931, 926, 927, and 928, respectively;
• (v) SEQ ID NOs:
• 228, 229, 230, 217, 218, and 219, respectively;
• (vi) SEQ ID NOs:
• 231, 232, 233, 220, 221, and 222, respectively;
• (vii) SEQ ID NOs:
• 234, 235, 236, 223, 224, and 225, respectively;
• or
• (viii) SEQ ID NOs:
• 944, 945, 988, 941, 942, and 943, respectively.