Chimeric antigen receptor (CAR) binding to BCMA, and uses thereof
AssigneesNanjing IASO Biotherapeutics Co., Ltd., Innovent Biologics (Suzhou) Co., Ltd.
InventorsJianfeng Zhou, Junjian Liu, Guang Hu, Yongkun Yang, Guangrong Meng, Wenjing Gao, Yuyu Wang, Panpan Niu
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Abstract
The invention provides a chimeric antigen receptor (CAR) which can specifically bind to a BCMA protein comprising a BCMA binding structural domain, a transmembrane domain, a co-stimulatory domain, and an intracellular signaling domain. The invention also provides uses of the CAR in treating diseases or conditions linked to the expression of BCMA.
Claims21
A chimeric antigen receptor (CAR), wherein the CAR comprises a B-cell maturation antigen (BCMA) binding domain, a transmembrane domain, a costimulatory domain and an intracellular signal transduction domain, the BCMA-binding domain comprises an antibody or a fragment thereof capable of specifically binding-a BCMA protein, and the antibody comprises a heavy chain complementary determining region 1 (HCDR1), a heavy chain complementary determining region 2 (HCDR2) and a heavy chain complementary determining region 3 (HCDR3), wherein the HCDR1 comprises the amino acid sequence of SEQ ID NO:
- 9, the HCDR2 comprises the amino acid sequence of SEQ ID NO:
- 10, and the HCDR3 comprises the amino acid sequence of SEQ ID NO:
- 11;
- and wherein the antibody comprises a light chain complementary determining region 1 (LCDR1), a light chain complementary determining region 2 (LCDR2) and a light chain complementary determining region 3 (LCDR3), and wherein the LCDR1 comprises the amino acid sequence of SEQ ID NO:
- 17, the LCDR2 comprises the amino acid sequence of SEQ ID NO:
- 18, and the LCDR3 comprises the amino acid sequence of SEQ ID NO:
- 19.
Dependencies are inferred from the claim text.