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US 11,026,972 B2Granted
Methods for generating macrophages with enhanced cancer phagocytosis
AssigneeGeorgia State University Research Foundation, Inc.
InventorsYuan Liu, Zhen Bian, Ke Zen
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Abstract
The present invention relates to compositions and methods variously useful in treating cancer, inhibiting graft rejection, and treating autoimmune disease. The compositions and methods include those in which macrophages are conditioned to down regulate or upregulate the expression or activity of SIRPα or its interaction with CD47.
Claims11
A method of generating macrophages with enhanced cancer phagocytosis, the method comprising:
- (a) providing a biological sample from a subject, wherein the biological sample comprises macrophages;
- (b) exposing the sample to an effective amount of a first composition comprising at least 100 units/ml IFNγ to suppress the expression or activity of signal regulatory protein α (SIRPα);
- and
- (c) exposing the sample from step (b) to an effective amount of a second composition that activates Protein kinase C (PKC)-Spleen tyrosine kinase (Syk) pathway, thereby generating macrophages with enhanced cancer phagocytosis.
1 more element
Dependencies are inferred from the claim text.