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US 11,026,969 B2Granted
High affinity T cell receptors and uses thereof
AssigneesFred Hutchinson Cancer Research Center, Adaptive Biotechnologies Corporation
InventorsThomas M. Schmitt, Philip D. Greenberg, Aude G. Chapuis, Harlan S. Robins, Anna M. Sherwood
Life of this patent
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Abstract
The present disclosure provides TCRs with high or enhanced affinity against various tumor associated antigens (including human Wilms tumor protein 1 (WT 1) epitopes and mesothelin epitopes), T cells expressing such high affinity antigen specific TCRs, nucleic acids encoding the same, and compositions for use in treating diseases or disorders in which cells overexpress one or more of these antigens, such as in cancer.
Claims17
A binding protein, comprising:
- (a) a T cell receptor (TCR) α-chain variable (Vα) domain having a CDR3 amino acid sequence shown in any one of SEQ ID NOS.:93-102, and a TCR β-chain variable (Vβ) domain;
- or
- (b) a Vαdomain of (a) and a Vβdomain having a CDR3 amino acid sequence shown in any one of SEQ ID NOS.:105-114;
- wherein the binding protein is capable of specifically binding to a WT-1 peptide:HLA complex on a cell surface independent of CD8 or in the absence of CD8.
1 more element
Dependencies are inferred from the claim text.