Back to results
US 11,026,965 B2Granted
Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto
AssigneeThe University of North Carolina at Chapel Hill
InventorsMark H. Schoenfisch, Haibao Jin
Life of this patent
Estimating the term…
Abstract
Disclosed herein are cyclodextrin molecules covalently modified to store and release nitric oxide, as well as methods of making and uses thereof. The covalently modified cyclodextrin molecules may be tailored, in several embodiments, to release nitric oxide in a controlled manner and are useful for reduction and/or eradication of bacteria and for the treatment of disease.
Claims23
A functionalized cyclodextrin represented by the following structure:
- wherein
- n is an integer selected from 1 to 8;
- m is an integer from 0 to 7;
- each instance of R1 is represented by —X1—((CH2)f′X2)g′((CH2)qX3)r—(CH2)h′H;
- wherein
- each of f′, q, g′, r, and h′ is independently selected from an integer from 0 to 4;
- each instance of X1, X2, or X3 is independently selected from O, NH, or a nitric oxide donating substituent;
- and at least one instance of X1, X2, or X3 in said functionalized cyclodextrin is
5 more elements
A functionalized cyclodextrin comprising:
- at least one ring unit of Formula I:
- wherein
- n is an integer selected from 1 to 8;
- R2 and R3 are independently selected from the group consisting of —OH, —O—((CH2)tO)u—H, —O—((CH2)t′O)u′—(CH2)vH, —O—(C1-5 alkyl), —NH—((CH2)cNH)d—H, —NH—((CH2)c′NH)d′—(CH2)eH, —X1—((CH2)fX2)g—(CH2)hH, and —X1—((CH2)f′X2)g′((CH2)qX3)r—(CH2)h′H;
- R1 is selected from the group consisting of —X1—((CH2)fX2)g—(CH2)h H and —X1—((CH2)f′X2)g′((CH2)h′H;
- wherein
- each of c, c′, d, d′, e, f, f′, g, g′, h, h′, q, r, t, t′, u, u′, and v is independently selected from an integer from 0 to 10;
- X1, X2, and X3 are independently selected from O, S, NH, or a nitric oxide donating substituent;
- wherein
- at least one of X1, X2, and X3 is said nitric oxide donating substituent represented by the following structure:
7 more elements
Dependencies are inferred from the claim text.