Esters of 2-deoxy-monosaccharides with anti proliferative activity
AssigneeBoard of Regents, The University of Texas System
InventorsWaldemar Priebe, Marcin Cybulski, Izabela Fokt, Stanislaw Skora, Charles Conrad, Timothy Madden
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Abstract
Compounds and methods of using the same to inhibit glycolysis and treat cancer and other diseases are disclosed.
Claims5
A method of treating brain or pancreatic cancer in a patient in need thereof comprising administering a therapeutically effective amount of one or more compounds of the Formula I:
- or a salt thereof, wherein:
- each R1, R2, R3 and R4 are independently H, or C(O)R5;
- at least two of R1, R2, R3 and R4 is C(O)R5;
- and
- each R5 is independently selected from C3-C7 straight- or branched-chain alkyl, C4-C10 alkylcycloalkyl, and C3-C7 cycloalkyl.
A method of treating brain or pancreatic cancer in a patient in need thereof comprising administering a therapeutically effective amount of the compound
A method of treating brain or pancreatic cancer in a patient in need thereof comprising administering a therapeutically effective amount of the compound
Dependencies are inferred from the claim text.