Small molecules for mouse satellite cell proliferation
AssigneePresident and Fellows of Harvard College
InventorsLee L. Rubin, Amy J. Wagers, Amanda K. W. Gee, Feodor D. Price
Life of this patent
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Abstract
The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject.
Claims16
A method of increasing satellite cell proliferation, the method comprising:
- contacting a satellite cell with a p38 MAPK inhibitor selected from the group consisting of SB 239063 (trans-1-(4-Hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole;
- HMSL10036-101-1);
- Doramapimod (BIRB 796;
- HMSL10169-101-1);
- SB 203580 (RWJ 64809;
- PB 203580;
- HMSL10167-101-1);
- Neflamapimod (VX-745;
- HMSL10168-101-1);
- PH-797804 (HMSL10439-101);
- VX-702 (HMSL10440-101);
- SB202190 (HMSL10441-101);
- Ralimetinib (LY2228820;
- HMSL10438-103);
- Losmapimod (GSK-AHAB;
- SB856553;
- GW856553X;
- HMSL10402-101);
- and any combinations thereof.
A method for muscle repair or regeneration in a subject, the method comprising administering a therapeutically effective amount of a p38 MAPK inhibitor selected from the group consisting of SB 239063 (trans-1-(4-Hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole;
- HMSL10036-101-1);
- Doramapimod (BIRB 796;
- HMSL10169-101-1);
- SB 203580 (RWJ 64809;
- PB 203580;
- HMSL10167-101-1);
- Neflamapimod (VX-745;
- HMSL10168-101-1);
- PH-797804 (HMSL10439-101);
- VX-702 (HMSL10440-101);
- SB202190 (HMSL10441-101);
- Ralimetinib (LY2228820;
- HMSL10438-103);
- Losmapimod (GSK-AHAB;
- SB856553;
- GW856553X;
- HMSL10402-101);
- and any combinations thereof.
Dependencies are inferred from the claim text.