Agent for preventing and/or treating Alzheimer's disease
AssigneeKyoto University
InventorsHaruhisa Inoue, Takayuki Kondo
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Abstract
The present invention provides a prophylactic or therapeutic agent for Alzheimer's disease (AD) containing a combination of two or more compounds selected from the group consisting of compounds shown by compound Nos. 1 to 130. Since these compounds are existing drugs that have already been confirmed actually for safety and pharmacokinetics in human, they can be a means for a pre-emptive treatment of people at risk of AD and in a stage before developing mild cognitive impairment (MCI).
Claims4
A method for reducing Aβ42/Aβ40 ratio in the brain of a subject, comprising administering to the subject an effective amount of each of bromocriptine and topiramate,
- wherein
- the effective amount of each of bromocriptine and topiramate is not more than a maximum nontoxic dose of each of bromocriptine and topiramate, and
- the Aβ42/Aβ40 ratio in the brain of the subject is reduced relative to the Aβ42/Aβ40 ratio in the brain of the subject in the absence of administering bromocriptine and topiramate to the subject.
Dependencies are inferred from the claim text.