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US 11,026,941 B2Granted
Concentrated, inhalable ciprofloxacin formulation
AssigneeGrifols, S.A.
InventorsDavid C. Cipolla, James Blanchard
Life of this patent
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Abstract
A concentrated inhalable formulation of an antibiotic drug such as ciprofloxacin is disclosed. The antibiotic is formulated with sodium acetate and liposome which incorporate antibiotic. The formulation is aerosolized and inhaled for treatment of respiratory tract infections and other medical conditions.
Claims16
A method of treating bronchiectasis in a patient, comprising:
- administering to lungs of the patient an aerosolized formulation comprising:
- free unencapsulated ciprofloxacin;
- a pharmaceutically acceptable excipient;
- and
- liposome-encapsulated ciprofloxacin wherein the liposomes are unilamellar, have an average particle size of 1 nanometer to 10 microns, and comprise cholesterol and hydrogenated soy phosphatidyl-choline (HSPC);
- wherein the liposomes maintain integrity when aerosolized and provide a ciprofloxacin release rate of 0.5% to 20% per hour over a period of time of 1-12 hours.
3 more elements
A method of treating bronchiectasis in a patient, comprising:
- administering to lungs of the patient an aerosolized formulation comprising:
- free unencapsulated ciprofloxacin;
- a pharmaceutically acceptable excipient;
- and
- liposome-encapsulated ciprofloxacin wherein the liposomes comprise cholesterol and hydrogenated soy phosphatidyl-choline (HSPC), are unilamellar, 90% or more of the liposomes maintain integrity when aerosolized, and provide a ciprofloxacin release rate of 0.5% to 20% per hour over a period of time of 1-12 hours.
2 more elements
Dependencies are inferred from the claim text.