Topical retinoid compositions
AssigneeDr. Reddy's Laboratories, Inc.
InventorsSateesh Kandavilli, Franklin Okumu, Manish M. Bankar, Sujit Kumar Dolai
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Abstract
The present application relates to topical compositions. In particular, the present application relates to a topical composition comprising retinoid as active agent, and pharmaceutically acceptable excipient(s), and a process of preparing such compositions. Further, the present application relates to method of using topical compositions for the treatment of skin disorders such as acne, rosacea, psoriasis etc.
Claims41
A topical lotion composition, comprising:
- a) a retinoid compound;
- b) an oil phase comprising one or more water immiscible substances;
- c) a hydrophilic phase comprising water;
- d) a thickener;
- e) one or more dermatologically acceptable excipient;
- and
- f) one or more surfactants in the range from about 0.01% w/w to about 10% w/w of the total weight of the composition;
- wherein the composition is free of propellant, and wherein the composition has pH from about 4 to about 7;
- wherein the composition excludes peanut oil.
A topical lotion composition comprising:
- a) tretinoin or a pharmaceutically acceptable salt thereof;
- b) at least one thickener comprising carbomer;
- c) at least one preservative selected from the group consisting of benzyl alcohol, methylparaben, and combinations thereof;
- d) an antioxidant comprising butylated hydroxytoluene;
- e) a moisturizer comprising glycerin;
- f) an emollient comprising mineral oil;
- g) a pH adjusting agent comprising trolamine;
- h) water;
- and
- i) one or more surfactants in the range from about 0.01% w/w to about 10% w/w of the total weight of the composition, wherein the one or more surfactants have a hydrophilic/lipophilic balance (HLB) of more than 10, and wherein the composition excludes surfactants selected from cetyl alcohol and stearyl alcohol;
- wherein the composition is free of propellant, and wherein the composition has pH from about 4 to about 7.
A topical lotion composition comprising:
- a) a retinoid compound;
- b) an oil phase comprising one or more water immiscible substances;
- c) a hydrophilic phase comprising water;
- d) a thickener;
- and
- e) one or more dermatologically acceptable excipient;
- wherein the composition is free of propellant;
- wherein the thickener is selected from carbomers, polyvinyl pyrrolidone, locust gum, polyvinyl alcohol, cross-linked polyacrylate polymer, guar gum, locust bean gum, polysaccharides, cellulose polymers and any combinations thereof;
- wherein the composition excludes peanut oil;
- and
- wherein a substantial amount of retinoid compound is in hydrophilic phase.
A topical lotion composition comprising:
- a) tazarotene or a pharmaceutically acceptable salt thereof;
- b) at least one thickener comprising carbomer;
- c) at least one preservative selected from the group consisting of, methylparaben, propylparaben, and combinations thereof;
- d) a chelating agent;
- e) an emollient comprising mineral oil;
- f) a pH adjusting agent;
- and
- g) water;
- wherein the composition is free of propellant;
- wherein the composition excludes peanut oil;
- and
- wherein a substantial amount of retinoid compound is in hydrophilic phase.
Dependencies are inferred from the claim text.