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US 11,026,933 B2Granted
Compositions and methods for treatment of cancer
AssigneeChildren's Hospital Medical Center
InventorsVladimir Kalinichenko, Tatiana Kalin
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AssigneeChildren's Hospital Medical Center
InventorsVladimir Kalinichenko, Tatiana Kalin
Estimating the term…
Disclosed are methods and compositions for the treatment of a proliferative disorder characterized by increased expression of the FOXM1 gene. Exemplary disorders include adenocarcinoma, melanoma, rhabdomyosarcoma, non-small cell lung cancer (NSCLC), head and neck squamous carcinoma, hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma, colon carcinoma, basal cell carcinoma, infiltrating ductal breast carcinoma, anaplastic astrocytoma, glioblastoma, pancreatic carcinoma, gastric cancer, acute myeloid leukemia, lung cancer, liver cancer, breast cancer, prostate cancer, a brain cancer. Kits and articles of manufacture comprising compositions for such treatment are also disclosed.
A method of treating a proliferative disorder due to increased expression of the FOXM1 gene, comprising the step of administering a composition comprising
A composition comprising RCM-1, or a pharmaceutically acceptable salt thereof, and one or more chemotherapeutic agents selected from a taxane, a platinum-based agent, an anthracycline, an alkylating agent, a vinca alkaloid, an epothilone, a histone deacetylase inhibitor, a topoisomerase I and II inhibitor, a kinase inhibitor, a nucleotide analog, a peptide antibiotic, and combinations thereof.
Dependencies are inferred from the claim text.