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US 11,026,930 B1Granted
Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
AssigneeSHY Therapeutics LLC
InventorsYaron R. Hadari, Luca Carta, Michael Schmertzler, Theresa M. Williams, Charles H. Reynolds, Rebecca Hutcheson
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Abstract
Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a novel method for assaying such compositions.
Claims16
An assay for identifying a compound as a modulator of Ras activity, wherein the assay comprises:
- a) contacting a compound with a Ras protein;
- b) incubating a cyanine-labeled GTP with the compound and the Ras protein;
- and
- c) measuring the amount of the cyanine-labeled GTP bound to the Ras protein.
1 more element
Dependencies are inferred from the claim text.