Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils

A method of treating a gastrointestinal disease associated with increased eosinophils comprising administering to a subject in need thereof a therapeutically effective amount of dexpramipexole, or a pharmaceutically acceptable salt thereof, wherein the gastrointestinal disease associated with increased eosinophils is selected from the group consisting of sclerosing cholangitis, irritable bowel disease, ulcerative colitis, eosinophilic esophagitis, eosinophilic gastroenteritis, inflammatory bowel disease, eosinophilic colitis, gluten sensitivity, Cronkhite-Canada syndrome, and any combination thereof.