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US 11,026,925 B2Granted
Angiotensin II receptor antagonist metabolite and NEP inhibitor composite and preparation method thereof
AssigneeShenzhen Salubris Pharmaceuticals Co., Ltd.
InventorsJie Yan, Wenjie Xu, Jianqiong Zhi, Song Li, Yang Wang, Yanxin Zheng
Life of this patent
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Abstract
Provided are a supramolecular composite comprising an angiotensin II receptor (AT1) blocking compound, a neutral endopeptidase inhibitor (NEPi), and a pharmaceutically acceptable cation. The invention further provides a method for preparing the composite and an application of the composite for preparing a pharmaceutical product for treating heart failure.
Claims22
A supramolecular complex of angiotensin II receptor metabolite and NEP inhibitor, wherein the formula unit of the supramolecular complex is:
- (aEXP3174.bAHU377).xCa.nA,
- wherein the molar ratio of a to b is from 1:0.25 to 1:4, x is from 0.5 to 3, A is water, methanol, ethanol, 2-propyl alcohol, acetone, ethyl acetate, methyl-tert-butyl ether, acetonitrile, methylbenzene or dichloromethane, and n is from 0 to 3.
Dependencies are inferred from the claim text.