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US 11,026,923 B2Granted
1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
AssigneeH. Lundbeck A/S
InventorsJan Kehler, Karsten Juhl, Mauro Marigo, Paulo Jorge Vieira Vital, Mikkel Jessing, Morten Langgård, Lars Kyhn Rasmussen, Carl Martin Sebastian Clementson
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Abstract
The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.
Claims17
A compound of formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- L is NH;
- R1 is H or C1-C5 alkyl;
- R2 is C1-C4 alkyl;
- R3 is methyl substituted with a 5-membered heteroaryl which is substituted with methyl, or is methyl substituted with a pyridinyl which is substituted with C1-C3 fluoroalkyl or C1-C3 alkoxy;
- and
- R4 is pyridinyl which is substituted with C1-C3 alkoxy.
4 more elements
Dependencies are inferred from the claim text.