Compositions comprising melatonin and flavonoids for use in the treatment of tumours resistant to chemotherapy
AssigneeProbiotical S.P.A.
InventorGiovanni Mogna
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Abstract
Compositions having at least one flavonoid of natural or synthetic origin in association with melatonin to increase the effectiveness of chemotherapeutic treatments used in human and veterinary medicine for the treatment of tumours are described. The compositions are in particular for the treatment of tumours resistant to the chemotherapeutic agents currently in use. The at least one flavonoid is selected from rutin, oxerutin, diosmin and hesperidin, preferably rutin.
Claims20
A method for treatment of chemoresistant tumours in an individual, the method comprising:
- administering to the individual a mixture comprising in effective amounts therefor:
- (i) rutin at a concentration of at least 20 μM;
- and
- (ii) melatonin at a concentration of at least 0.1 mM,
- wherein the chemoresistant tumour is breast cancer in woman.
A method for treatment of neoplasias and for inhibition or suppression of chemoresistance to antiblastics in an individual and/or radioresistance to radiotherapy, the method comprising:
- administering to the individual a mixture comprising in effective amounts therefor:
- (i) rutin at a concentration of at least 20 μM;
- and
- (ii) melatonin at a concentration of at least 0.1 mM;
- and optionally further comprising
- (iv) at least one compound selected from the group consisting of arctigenin, arctiine, berberine, berbamine, sanguinarine, chelerythrine and harpagophytum procumbens, as such or in the form of plant extracts containing said compounds,
- wherein the neoplasia is a breast cancer in woman.
A method of treating metastatic breast cancer, the method comprising:
- administering to an individual an antimetastatic composition comprising in effective amounts therefor:
- (i) rutin at a concentration of at least 20 μM;
- and
- (ii) melatonin at a concentration of at least 0.1 mM,
- wherein the individual is a woman having metastatic breast cancer.
Dependencies are inferred from the claim text.