Method of preventing or treating a pulmonary disease or condition
AssigneeThe Board of Trustees of the University of Illinois
InventorsAnantha Harijith, Viswanathan Natarajan, Roberto F. Machado, Jeffrey Jacobson
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Abstract
A pharmaceutical composition for aerosol administration and method of preventing or treating a pulmonary disease or condition in a subject with a SphK1 inhibitor are provided.
Claims8
A method of treating a pulmonary disease or condition in a subject comprising administering to a subject in need of treatment an effective amount of a SphK1 inhibitor to treat the subject's pulmonary disease or condition, wherein the SphK1 inhibitor
- (a) exhibits at least a 20-fold greater selectivity for SphK1than SphK2;
- and
- (b) is cell permeable, has an IC50 value of less than 10 μM, or has a Ki of less than 10 μM, or a combination thereof.
A method of treating a pulmonary disease or condition in a subject comprising administering to a subject in need of treatment an effective amount of [(2R)-1-[[4-[[3-(benzenesulfonyl methyl)-5-methylphenoxy]methyl]phenyl]methyl] pyrrolidin-2-yl] methanol (PF-543), or a pharmaceutically acceptable salt thereof, to treat the subject's pulmonary disease or condition, wherein the pulmonary disease or condition comprises restrictive lung disease, bronchiectasis, bronchiolectasis, bronchitis, emphysema, a diffuse interstitial lung disease, a diffuse infiltrative lung disease, serofibrinous pleuritis, suppurative pleuritis, hemorrhagic pleuritis, idiopathic pulmonary fibrosis, bronchopulmonary dysplasia, hyperoxia or oxygen-induced lung injury, injury due to drug or chemotherapeutic toxicity, radiation-induced injury, or chemical injury.
Dependencies are inferred from the claim text.