Treatment for non-alcoholic fatty liver diseases
AssigneeDsm IP Assets B.V.
InventorsSzabolcs Peter, Joseph Schwager
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Abstract
Mixtures of vitamin E and polyunsaturated fatty acids (PUFAs) are provided as agents for the prevention, control and/or treatment of conditions associated with excessive fat accumulation in the liver which is not caused by alcohol abuse, including control and/or treatment of non-alcoholic steatosis in the liver—known as non-alcoholic fatty liver disease (NAFLD)—and/or non-alcoholic steatohepatitis (NASH) in a subject in need thereof.
Claims6
A method of treating a condition requiring modulation of inflammatory response associated with accumulation of fat in the liver which is not caused by consumption/abuse of alcohol, which comprises administering to a patient in need thereof a composition comprising vitamin E and ω-3 docosahexaenoic acid (DHA), wherein the ratio of vitamin E to the DHA provides a synergistic effect and is in the range of about 1:1 to about 1:2, wherein the vitamin E is calculated as α-tocopherol, wherein the composition is administered as a daily dose of about 500 to about 2000 mg vitamin E and about 400 mg to about 4000 mg DHA, and wherein the inflammatory response is non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH).
Dependencies are inferred from the claim text.