α- and γ-truxillic acid derivatives and pharmaceutical compositions thereof

A mixture of compounds having the structure:

• wherein the mixture is enantiomerically enriched in a compound having the structure:
• wherein
• one of R1 or R2 is —C(═O)OR13,
• wherein R13 is substituted C1-10 alkyl, C2-10 alkenyl or C2-10 alkynyl;
• and
• the other of R1 or R2 is —C(═O)OH,
• wherein the substituted C1-10 alkyl is substituted with halogen, alkoxy, heteroaryloxy, sulfonyl, nitro, mercapto, sulfanyl, cyano, amino, carbamoyl, carboxyl or acyl;
• R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are each independently, H, halogen, —NO2, —CN, —NHR15, —OR15 or CF3;
• wherein R15 is H, C1-10 alkyl, C2-10 alkenyl or C2-10 alkynyl;
• or a pharmaceutically acceptable salt thereof.