US 11,026,898 B2Granted

Eutectic formulations of cyclobenzaprine hydrochloride

AssigneeTonix Pharma Holdings Limited

InventorsSeth Lederman, Marino Nebuloni

Life of this patent

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Abstract

The present invention relates to pharmaceutical compositions and methods of manufacturing the same, comprising a eutectic of Cyclobenzaprine HCl and mannitol.

Claims23

Dependent claims

A pharmaceutical composition comprising a eutectic of δ-mannitol and Cyclobenzaprine HCl, wherein the eutectic comprises 65%±2% Cyclobenzaprine HCl and 35%±2% δ-mannitol by weight.

Dependencies are inferred from the claim text.

Facts

Application: 16/518,338Filed 22 Jul 2019 · continuation
Priority: 18 Sep 2014
Published: US 2019/0336458 A17 Nov 2019
Granted: 8 Jun 2021
Term ends: Not estimatedThe source records don’t support an estimate.

Classification13 codes

A61K 31/135
Amines: having aromatic rings , e.g. ketamine, nortriptyline
A61K 9/1623
Organic compounds, e.g. phospholipids, fats: sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
A61K 9/2018
Organic compounds, e.g. phospholipids, fats: sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
A61P 21/00
Drugs for disorders of the muscular or neuromuscular system

Family

Application62/052,238Us provisional application · filed 18 Sep 2014
PCT/US2015/051068Parent of this continuation · filed 18 Sep 2015
US 2019/0336458 A1Pre-grant publication · published 7 Nov 2019
Application15/511,287Parent of this continuation
US 10,357,465 B2Parent of this continuation
US 2017/0281568 A1Published application
US 11,026,898 B2This patent

From the US filing history. Foreign family members aren’t listed.

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