Lipid nanoparticles and use thereof to deliver RNA polynucleotides
AssigneeMassachusetts Institute of Technology
InventorsDarrell J. Irvine, Ron Weiss, Tasuku Kitada, Mariane Melo, Yuan Zhang
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Abstract
Disclosed herein are lipid nanoparticles comprising 1,2-dioleoyl-3-trimethylammonium propane (DOTAP), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), cholesterol, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000](DSPE-PEG2000), compositions including such lipid nanoparticles, and methods of treatment using such lipid nanoparticles and compositions.
Claims21
A lipid nanoparticle comprising 1,2-dioleoyl-3-trimethylammonium propane (DOTAP), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), cholesterol, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (DSPE-PEG2000), wherein the molar ratio of DOTAP:
- DSPC:
- cholesterol:
- DSPE-PEG2000 is 40:10:48:2.
Dependencies are inferred from the claim text.