Methods for improving vision
AssigneeEye Therapies LLC
InventorGerald Horn
Life of this patent
Estimating the term…
Abstract
The present invention is directed to methods for improving night vision and visual performance in low light conditions comprising ophthalmological administration of compositions comprising low dose brimonidine and a vehicle for improved performance.
Claims11
A method of improving night vision comprising administering to an eye of subject in need thereof a composition comprising from about 0.025% to about 0.050% w/v brimonidine, from about 1% to about 5% w/v of polysorbate, mannitol at about 0.1-2.0%, hydroxypropyl methyl cellulose (HPMC) at about 0.10-1.20%, NaCl at about 0.4%, BAK at about 0.01%, and boric acid at about 5 mM wherein w/v denotes weight by total volume of the composition and wherein the composition has a pH of about 7.5, wherein the improvement of night vision occurs for at least four weeks without tachyphylaxis.
A method of improving eye fatigue under a luminance level below 500 candela per square meter (cd/m2) comprising administering to an eye of subject in need thereof a composition comprising from about 0.01% to about 0.05% w/v brimonidine, from about 1% to about 5% w/v of a polysorbate, mannitol 0.10-2.0%, HPMC 0.10%-1.20%, NaCl at about 0.4%, BAK at about 0.01%;
- boric acid at about 5 mM wherein w/v denotes weight by total volume of the composition and wherein the composition has a pH of about 7.5.
A method of improving sports performance under a luminance level below 500 candelas per square meter (cd/m2) comprising administering to an eye of subject in need thereof a composition comprising from about 0.01% to about 0.05% w/v brimonidine, from about 1% to about 5% w/v of polysorbate, mannitol 0.1-2.0%, HPMC 0.10-1.20%, NaCl at about 0.4%, BAK at about 0.01%, boric acid at about 5 mM, wherein w/v denotes weight by total volume of the composition and wherein the composition has a pH of about 7.5.
A method of reducing eye fatigue from indoor lighting under a luminance level below 500 candelas per square meter (cd/m2) comprising administering to an eye of subject in need thereof a composition comprising from about 0.01% to about 0.05% w/v brimonidine, from about 1% to about 5% w/v of polysorbate, mannitol 0.1-2.0%, HPMC 0.10-1.20%, NaCl at about 0.4%, BAK at about 0.01%, boric acid at about 5 mM, wherein w/v denotes weight by total volume of the composition and wherein the composition has a pH of about 7.5.
Dependencies are inferred from the claim text.