Computational simulation platform for planning of interventional procedures

A system for simulation and planning of interventional procedures, comprising:

• one or more medical imaging devices;
• one or more computer systems communicatively coupled to the one or more medical imaging devices, the one or more computer systems being configured to:
• generate a three-dimensional (3D) reconstruction of a vessel lumen and a surface of the vessel lumen based on invasive or non-invasive imaging data received from the one or more medical imaging devices;
• generate a mesh of the 3D reconstructed vessel lumen and surface of the vessel lumen;
• assign material properties to the 3D reconstructed surface of the vessel lumen based on the invasive or non-invasive imaging data received from the one or more medical imaging devices, wherein the assigning of the material properties to the 3D reconstructed surface of the vessel lumen based on the invasive or non-invasive imaging data includes:
• determining wall or plaque thickness, lumen area, plaque eccentricity and plaque constituents based on the invasive or non-invasive imaging;
• dividing the vessel lumen into sequential zones of plaque material;
• and assigning a quarter number ranging from purely calcium plaque material to purely lipid plaque material;
• import design and material properties of stents and balloons;
• generate a mesh of a stent and balloon;
• position the meshed stent and balloon within the mesh of the 3D reconstructed vessel lumen and surface of the vessel lumen, wherein the meshed stent and balloon in their crimped state are computationally positioned and bent in the mesh of the 3D reconstructed vessel lumen and surface of the vessel lumen;
• perform balloon pre-dilation, stenting and balloon post-dilation computational simulations with the mesh of the 3D reconstructed vessel lumen and surface of the vessel lumen;
• and
• assess stent and vessel morphometric and biomechanical measures based on the computational simulations.

A computational simulation platform for interventional procedures planning, comprising a computer-implemented method that includes:

• generating a three-dimensional (3D) reconstruction of a vessel lumen and a surface of the vessel lumen based on invasive or non-invasive imaging;
• generating a mesh of the 3D reconstructed vessel lumen and surface of the vessel lumen;
• assigning material properties to the 3D reconstructed surface of the vessel lumen;
• importing design and material properties of stents and balloons;
• generating a mesh of a stent and balloon;
• positioning the meshed stent and balloon within the 3D reconstructed vessel lumen and surface of the vessel lumen;
• performing balloon pre-dilation, stenting and balloon post-dilation computational simulations with the 3D reconstructed vessel lumen and surface of the vessel lumen;
• and
• assessing stent and vessel morphometric and biomechanical measures based on the computational simulations,
• wherein the material properties are assigned to the 3D reconstructed surface of the vessel lumen based on the invasive or non-invasive imaging, and
• wherein the assigning of the material properties to the 3D reconstructed surface of the vessel lumen based on the invasive or non-invasive imaging includes:
• determining wall or plaque thickness, lumen area, plaque eccentricity and plaque constituents based on the invasive or non-invasive imaging;
• dividing the vessel lumen into sequential zones of plaque material;
• and assigning a quarter number ranging from purely calcium plaque material to purely lipid plaque material.