Analyte sensor

A glucose monitoring system comprising:

• a first component comprising:
• a transcutaneous glucose sensor configured for transcutaneous implantation into a body of a host, the transcutaneous glucose sensor comprising:
• an electrode;
• and
• a membrane comprising at least one enzyme;
• an electrical contact comprising a material associated with a first durometer hardness;
• and
• a sealing member at least partially surrounding a portion of the transcutaneous glucose sensor and at least partially surrounding the elastomeric electrical contact, the elastomeric sealing member comprising a material associated with a second durometer hardness that is less than the first durometer hardness;
• and
• a second component comprising sensor electronics operably connectable to the transcutaneous glucose sensor, wherein the sensor electronics are not radiation sterilized, wherein the second component and the first component are configured to be physically coupled during sensor use;
• wherein the first component is sterilized with radiation sterilization by exposing the transcutaneous glucose sensor to an electron beam radiation at a dose of from 12 kGy to 50 kGy.

A method of making a glucose concentration measuring system comprising:

• manufacturing at least one transcutaneous glucose sensor, wherein the at least one transcutaneous glucose sensor comprises:
• an in vivo portion configured for insertion into a body of a host during sensor use;
• and
• an ex vivo portion configured to remain outside the body of the host during sensor use;
• measuring a glucose sensitivity characteristic associated with the at least one transcutaneous glucose sensor;
• assigning information associated with a sensor sensitivity to the at least one transcutaneous glucose sensor based at least in part on the glucose sensitivity characteristic measurement;
• storing the information associated with the sensor sensitivity in sensor electronics;
• configuring a processor to use the information associated with the sensor sensitivity to calibrate sensor data derived from the at least one transcutaneous glucose sensor after implantation of the in vivo portion of the at least one transcutaneous glucose sensor into the body of the host, without use of a reference glucose concentration value obtained after implantation of the in vivo portion of the at least one transcutaneous glucose sensor into the body of the host;
• and
• sterilizing the at least one transcutaneous glucose sensor by exposing the at least one transcutaneous glucose sensor to an electron beam radiation at a dose of from 12 kGy to 50 kGy.

A method of making a glucose concentration measuring system comprising:

• manufacturing at least one transcutaneous glucose sensor, wherein the at least one transcutaneous glucose sensor comprises:
• an in vivo portion configured for insertion into a body of a host during sensor use;
• and
• an ex vivo portion configured to remain outside the body of the host during sensor use;
• measuring a glucose sensitivity characteristic associated with the at least one transcutaneous glucose sensor;
• assigning information associated with a sensor sensitivity to the at least one transcutaneous glucose sensor based at least in part on the glucose sensitivity characteristic measurement;
• storing the information associated with the sensor sensitivity in sensor electronics;
• configuring a processor to use the information associated with the sensor sensitivity to calibrate sensor data derived from the at least one transcutaneous glucose sensor after implantation of the in vivo portion of the at least one transcutaneous glucose sensor into the body of the host, without use of a reference glucose concentration value obtained after implantation of the in vivo portion of the at least one transcutaneous glucose sensor into the body of the host;
• sterilizing the at least one transcutaneous glucose sensor by exposing the at least one transcutaneous glucose sensor to an electron beam;
• and
• sterilizing the sensor electronics by exposing the sensor electronics to a gas.