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AssigneeEndoderma Co., Ltd.
InventorsJae Soo Kim, Soon Chang Kwon, Sang Jin Park
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The present invention relates to a hyaluronic acid microstructure having excellent solubility characteristics. More specifically, the present invention relates to a biodegradable microstructure comprising crosslinked hyaluronic acid and having excellent solubility characteristics during skin penetration. When the microstructure of the present invention is penetrated into the skin, the solubility characteristics in the skin are excellent, the dissolution rate in the skin can be easily controlled according to the content ratio of the crosslinked hyaluronic acid, and, while effective ingredients provided on the microstructure can be stably delivered into the skin, the release rate of the provided effective ingredients can be easily controlled, and thus the present invention can be used as a transdermal delivery system for pharmacologically active materials or skin improvement materials.
A skin penetrating microneedle comprising, as a main ingredient, i) crosslinked hyaluronic acid or ii) a mixture of crosslinked hyaluronic acid and non-crosslinked hyaluronic acid, wherein, relative to the weight of the overall hyaluronic acid, the content of the crosslinked hyaluronic acid is 5-100% (w/w) and the content of the non-crosslinked hyaluronic acid is 0-95% (w/w),
Dependencies are inferred from the claim text.