Homogeneous engineered phage populations
AssigneeMassachusetts Institute of Technology
InventorsAngela M. Belcher, Uyanga Tsedev, Fred Lam
Life of this patent
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Abstract
Provided are engineered phages populations, which are homogeneous in length, as well as methods of making and methods of using such phages. Also provided are engineered chlorotoxin-phages as well as their methods of making and using. The disclosed homogeneous phage populations and chlorotoxin-phages may be used, for example, for treating and/or imaging tumors, such as central nervous system tumors.
Claims54
A homogeneous engineered filamentous phage population, wherein at least 70% of filamentous phages in the phage population have a length within 15% or within 8 nm of a length value, which is selected from 10 nm to less than the corresponding wild type filamentous phage length, wherein the phage population has a count of at least 1e13 pfu.
A phage comprising chlorotoxin expressed by a coat protein of the phage, wherein the phage is an engineered phage, which is a part of a homogeneous engineered phage population, wherein at least 70% of phages in the phage population have a length within 15% or within 8 nm of a length value, which is selected from 10 nm to less than the corresponding wild type phage length.
Dependencies are inferred from the claim text.