US 10,946,105 B2 · Peptides derived from transient receptor potential cation channel subfamily M member 1 (TRPM1), complexes comprising such peptides bound to MHC molecules

Abstract

The present invention relates to novel peptides derived from Transient receptor potential cation channel subfamily M member 1 (TRPM1), complexes comprising such peptides bound to recombinant MHC molecules, and cells presenting said peptide in complex with MHC molecules. Also provided by the present invention are binding moieties that bind to the peptides and/or complexes of the invention. Such moieties are useful for the development of immunotherapeutic reagents for the treatment of diseases such as cancer.

Claims18

Dependent claims

A method of treating cancer in a subject, comprising:

administering to the subject a therapeutically effective amount of a binding moiety capable of specifically binding a polypeptide
wherein the polypeptide comprises:
(a) the amino acid sequence of any one of SEQ ID NOS:
1-16, or
(b) the amino acid sequence of any one of SEQ ID NOs:
1-16 with the exception of 1, 2 or 3 amino acid substitutions and/or 1, 2 or 3 amino acid insertions, and/or 1, 2 or 3 amino acid deletions, and
wherein the polypeptide is capable of forming a complex with a Major Histocompatibility Complex (MHC) molecule.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/778,206Filed 23 Nov 2016

Priority

GB 1520550.323 Nov 2015

Published

US 2018/0344867 A16 Dec 2018

Granted

16 Mar 2021

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

A61K 47/6849
The modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site: the antibody targeting a receptor, a cell…
A61K 47/42
Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates: proteins; Polypeptides; Degradation products thereof; Derivatives…
A61K 47/6855
The antibody targeting a determinant of a tumour cell: the tumour determinant being from breast cancer cell
A61P 35/00
Antineoplastic agents

Peptides derived from transient receptor potential cation channel subfamily M member 1 (TRPM1), complexes comprising such peptides bound to MHC molecules

Life of this patent

Peptides derived from transient receptor potential cation channel subfamily M member 1 (TRPM1), complexes comprising such peptides bound to MHC molecules

Life of this patent

Abstract

Claims18