Aberrant cell-restricted immunoglobulins provided with a toxic moiety
AssigneeApo-Tb.V.
InventorsJohan Renes, Paul Steverink, Ralph Alexander Willemsen
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Abstract
Described are immunoglobulins provided with a toxic moiety, comprising at least an immunoglobulin variable region that specifically binds to an MHC-peptide complex preferentially associated with aberrant cells. These immunoglobulins provided with a toxic moiety are preferably used in selectively modulating biological processes. The provided immunoglobulins provided with a toxic moiety are of particular use in pharmaceutical compositions for the treatment of diseases related to cellular aberrancies, such as cancers and autoimmune diseases.
Claims11
An immunoglobulin conjugated to a toxic moiety comprising at least an immunoglobulin region that specifically binds to an MHC-I-MAGE peptide complex,
- wherein the immunoglobulin region comprises a Vh domain comprising SEQ ID NO:
- 1;
- wherein the MAGE peptide of the MHC-I-MAGE peptide complex is derived from intracellular MAGE associated with aberrant cells;
- and
- wherein the MAGE peptide is a multi-MAGE epitope.
Dependencies are inferred from the claim text.