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US 10,946,100 B2Granted
Polymers including active agents
AssigneeMicroVention, Inc.
InventorsGregory M. Cruise, Clayton G. Harris, Michael J. Constant
Life of this patent
Estimating the term…
Abstract
Polymers are described herein comprising: a reaction product of a prepolymer solution including at least one macromer and at least one visualization agent; and an active agent electrostatically bound to the polymer filament or chemically bound to the at least one monomer; wherein the polymer filament does not include metallic support members.
Claims23
A method of forming a therapeutic polymer filament comprising:
- reacting a prepolymer solution including:
- at least one macromer selected from ethoxylated pentaerythritol, ethoxylated trimethylolpropane, or a combination thereof,
- at least one visualization agent, and
- a polymerizable pharmaceutical agent having a structure
- wherein R1 is
- wherein each R2 and R3 can independently be H, CH3, C2-C6 alkyl, C2-C6 substituted with a halogen or other C1-C6 alkyl, NH2, CO2, ON, CF3, F, Cl, Br, I, CCl3, OH, or CH2OH;
- n is 1, 2, 3, or 4;
- m is 1, 2, 3, or 4;
- X1, X2, X3, and X4 are each N or CH;
- and
- X5 is O, CH2, or NH;
- and
- p is 0, 1, 2, 3 or 4
- thereby forming the therapeutic polymer filament wherein the polymerizable pharmaceutical agent is chemically bound to the therapeutic polymer filament.
11 more elements
A method of forming a therapeutic polymer filament comprising:
- reacting a prepolymer solution including:
- at least one macromer selected from poly(ethylene glycol), poly(propylene glycol), poly(tetramethylene oxide), ethoxylated pentaerythritol, ethoxylated trimethylolpropane, poly(vinyl alcohol), or a combination thereof, and
- a polymerizable pharmaceutical agent having a structure
- wherein R1 is
- wherein each R2 and R3 can independently be H, CH3, C2-C6 alkyl, C2-C6 substituted with a halogen or other C1-C6 alkyl, NH2;
- CO2, ON, CF3, F, Cl;
- Br, I, CCl3, OH, or CH2OH;
- n is 1, 2, 3, or 4;
- m is 1, 2, 3, or 4;
- X1, X2, X3, and X4 are each N or CH;
- and
- X5 is O, CH2, or NH;
- and
- p is 0, 1, 2, 3 or 4
- thereby forming the therapeutic polymer filament wherein the polymerizable pharmaceutical agent is chemically bound to the therapeutic polymer filament.
12 more elements
A method of forming a therapeutic polymer filament comprising:
- reacting a prepolymer solution including:
- at least one macromer selected from polyethylene glycol), poly(propylene glycol), poly(tetramethylene oxide), ethoxylated pentaerythritol, ethoxylated trimethylolpropane, poly(vinyl alcohol), or a combination thereof, and
- a polymerizable pharmaceutical agent having a structure
- thereby forming the therapeutic polymer filament wherein the polymerizable pharmaceutical agent is chemically bound to the therapeutic polymer filament.
1 more element
Dependencies are inferred from the claim text.