Fractionated radiotherapy and chemotherapy with an oxygen therapeutic

A method of treating glioblastoma by multi-fraction radiotherapy or chemotherapy, comprising:

• concomitantly or up to 120 minutes prior to each fraction of radiation therapy or concomitantly with chemotherapy, administering to a subject suffering from glioblastoma a water emulsion of perfluoropentane to the mammal, wherein the perfluoropentane emulsion comprises a viscosity modifier, a fluorosurfactant, and about 1% to 5% w/vol of perfluoropentane;
• and
• simultaneously administering to said mammal carbogen or supplemental oxygen,
• wherein the perfluoropentane emulsion is administered at a dosage in the range from about 0.05 cc/kg to about 0.3 cc/kg.