Nitrobenzaldehyde proton release for manipulation of cellular acidosis
AssigneeBoard of Regents, The University of Texas System
InventorsMatthew Gdovin, Brian O'Grady, Elma Frias, Haley Hazlett
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Abstract
Certain embodiments are directed to photo-activated compounds for the manipulation of pH in a cell. In certain aspects the photo-activated compound is 2-nitrobenzaldehyde (NBA). Photo-activated compounds can be used as a targeted therapy for a variety of disease states and conditions, such as cancer.
Claims14
A method for treating a cancerous tumor in a patient comprising (i) administering 2-nitrobenzaldehyde to the cancerous tumor in the patient, wherein the 2-nitrobenzaldehyde is internalized by a cancerous tumor cell forming a 2-nitrobenzaldehyde containing cancer cell, and (ii) irradiating the tumor having 2-nitrobenzaldehyde containing cancer cell with a light source to reduce the internal pH of the 2-nitrobenzaldehyde containing cancer cell below 6.4 and inducing cell death in response to cellular acidosis of the 2-nitrobenzaldehyde containing cancer cell and treating the tumor.
A method for inducing cell death in response to cellular acidosis of a tumor cell comprising (i) administering 2-nitrobenzaldehyde to a tumor cell where it is internalized by the tumor cell, and (ii) irradiating the tumor cell with a light source to reduce the pH of said cell below 6.4.
Dependencies are inferred from the claim text.