US 10,946,085 B2 · Streptococcus uberis extract as an immunogenic agent

Abstract

The present invention relates to an extract of Streptococcus uberis as an immunogenic agent. It also relates to a process for obtaining said agent which comprises incubating a biofilm-producing S. uberis strain to obtain a biofilm and thermally treating the biofilm obtained. It relates also to a pharmaceutical composition comprising teichoic acids, preferably lipoteichoic acids, for use in the prevention and/or treatment of mastitis and/or infections caused by Streptococcus sp. or by biofilm-producing bacteria. The present invention also relates to a vaccine which comprises said immunogenic agent and to said vaccine and immunogenic agent for use in the prevention and/or treatment of infections caused by Streptococcus sp., especially in the prevention and/or treatment of mastitis caused by S. uberis. It also relates to a vaccination kit which comprises said agent or vaccine.

Claims9

Dependent claims

An immunogenic agent comprising a soluble extract of a heat-treated biofilm, wherein the soluble extract of the heat-treated biofilm is obtained by a process comprising:

a) incubating a biofilm-producing S. uberis strain in a culture medium to obtain a biofilm,
b) recovering the biofilm from the culture medium and discarding the culture medium and bacterial cells in suspension,
c) subjecting the biofilm obtained in step b) to a heat treatment carried out at a temperature comprised from 80° C. to 130° C., and,
d) discarding the insoluble fraction obtained after the heat treatment of step c) and preserving the soluble extract, wherein the soluble extract of the heat-treated biofilm thereby is the immunogenic agent.

1 more element

Dependencies are inferred from the claim text.

Streptococcus uberis extract as an immunogenic agent

Life of this patent

Streptococcus uberis extract as an immunogenic agent

Life of this patent

Abstract

Claims9