Immunomodulatory compositions and methods of use thereof
AssigneesAgrawal Babita, Kumar Rakesh
InventorsBabita Agrawal, Rakesh Kumar
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Abstract
The present disclosure provides immunomodulatory compositions comprising heat-killed Caulobacter crescentus (HKCC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising HKCC to the individual.
Claims10
A method of modulating an antigen-specific immune response in an individual, the method comprising administering to the individual an effective amount of an immunomodulatory composition comprising:
- a) heat-killed Caulobacter spp.;
- b) a pathogen-derived antigen, or a tumor-associated antigen;
- and
- c) a pharmaceutically acceptable excipient;
- wherein the Caulobacter spp. is selected from the group consisting of Caulobacter vibroides, Caulobacter henricii, Caulobacter fusiformis, Caulobacter intermedius, and Caulobacter subvibroides, and the composition is administered via an oral, nasal, subcutaneous, intramuscular, topical or mucosal route of administration.
A method of reducing tumor progression or an infection in an individual having a disease selected from the group consisting of cancer and an infectious disease, wherein the infectious disease is caused by a virus, a bacterium, or a fungus, the method comprising administering to the individual a composition comprising:
- a) heat-killed Caulobacter spp.;
- and
- b) a pharmaceutically acceptable excipient;
- wherein the Caulobacter spp. is selected from the group consisting of Caulobacter vibroides, Caulobacter henricii, Caulobacter fusiformis, Caulobacter intermedius, and Caulobacter subvibroides, and the composition is administered via an oral, nasal, subcutaneous, intramuscular, topical or mucosal route of administration.
A method of enhancing the efficacy and/or reducing the toxicity of an anticancer therapeutic treatment in an individual, the method comprising administering to the individual an effective amount of an immunomodulatory composition comprising:
- a) heat-killed Caulobacter spp.;
- and
- b) a pharmaceutically acceptable excipient;
- wherein the Caulobacter spp. is selected from the group consisting of Caulobacter vibroides, Caulobacter henricii, Caulobacter fusiformis, Caulobacter intermedius, and Caulobacter subvibroides, and the composition is administered via an oral, nasal, subcutaneous, intramuscular, topical or mucosal route of administration.
Dependencies are inferred from the claim text.