Peptide inhibitors of twist
AssigneeCity of Hope
InventorCarlotta A. Glackin
Life of this patent
Estimating the term…
Abstract
The disclosure provides, inter alia, compositions comprising TWIST peptide inhibitors and optionally one or more anti-cancer agents, and methods of using the compositions for the treatment of cancer.
Claims20
A composition comprising a TWIST peptide or a nucleic acid encoding said TWIST peptide covalently bound to a delivery vehicle, wherein said TWIST peptide comprises a WR domain of TWIST1.
A fusion protein comprising a TWIST peptide covalently attached to a cell-penetrating peptide, wherein said TWIST peptide comprises a WR domain of TWIST1.
A composition comprising a TWIST peptide or a nucleic acid encoding said TWIST peptide bound to a delivery vehicle, wherein
- said TWIST peptide comprises a WR domain of TWIST1, and wherein
- said delivery vehicle is a nanoparticle, a vector, a virus capsid, a liposome, a liposomal vesicle, a lipoplex, a polyplex, a dendrimer, a macrophage, a polymer, a hybrid particle, or a lipid vehicle.
Dependencies are inferred from the claim text.