Extracellular vesicles with enhanced potency
AssigneeUnited Therapeutics Corporation
InventorsSarah Hogan, Roger Marquez Ilagan, Maria Pia Rodriguez, Carolina Medrano, John Cheadle
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Abstract
Provided are methods for isolating potent extracellular vesicle or exosome populations from mesenchymal stromal cells, and the use of the isolated extracellular vesicles or exosomes in treating vasculopathy, including pulmonary hypertension, bronchopulmonary dysplasia, and disease and conditions associated with mitochondrial dysfunction.
Claims20
A method of treating pulmonary hypertension, comprising administering to a subject in need thereof isolated extracellular vesicles or exosomes obtained from mesenchymal stromal cells, wherein the isolated extracellular vesicles or exosomes are selected to have increased expression of one or more expression products of genes in the glycolysis pathway as compared to the average amount of the expression products in all extracellular vesicles or exosomes obtained from the mesenchymal stromal cells.
Dependencies are inferred from the claim text.