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US 10,946,033 B2Granted
2′-substituted-N6-substituted purine nucleotides for RNA virus treatment
AssigneeAtea Pharmaceuticals, Inc.
InventorsJean-Pierre Sommadossi, Adel Moussa
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Abstract
The use of described compounds or pharmaceutically acceptable salts or compositions thereof for the treatment of a host infected with an RNA virus other than HCV, or other disorder more fully described herein.
Claims23
A method to treat a host infected with Dengue Fever comprising administering an effective amount of a compound of the formula:
- or a pharmaceutically acceptable salt thereof to treat the host in need thereof;
- wherein:
- R7 is C1-6alkyl, C3-7cycloalkyl, or aryl;
- R8 is hydrogen or C1-6alkyl;
- R9a and R9b are independently selected from hydrogen, C1-6alkyl, cycloalkyl, aryl and aryl(C1-3alkyl)-;
- R10 is hydrogen, C1-6alkyl, C1-6haloalkyl, or C3-7cycloalkyl;
- and
- R11 is C1-6alkyl, cycloalkyl, C2-6alkynyl, C2-6alkenyl, or acyl.
5 more elements
A method to treat a human infected with Dengue Fever comprising administering an effective amount of a compound of the formula:
- or a pharmaceutically acceptable salt thereof to treat the human in need thereof.
A method to treat a human infected with Dengue Fever comprising administering an effective amount of a compound of the formula:
- or a pharmaceutically acceptable salt thereof to treat the human in need thereof.
Dependencies are inferred from the claim text.